Is it safe to take vicodin when you are on ketoconazole?

Answer:
you should consult with your doctor or pharmocyst

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Well, I was watching House, M.D. the other night and they said...... ASK YOUR DOCTOR MEDICAL QUESTIONS, not a bunch of net people.

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Both medicines are stressful on your liver. You also risk interfering with the way the ketoconazole works. You should avoid taking them together if possible.

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Yes, you can take vicodin and ketoconazole together, but this combination would warrant you to monitor this drug therapy. Ketoconazole is a an inhibitor of the liver enzyme that breaks down vicodin, while vicodin is an inducer for this liver enzyme. If both of these medications are taken at once, you might not have enough of this liver enzyme to metabolize or break down the vicodin, which could diminish the proper therapeutic effect for your pain management (this would cause vicodin to stay in your system longer than wanted, allowing it to build up and possibly lead to toxic effects). While taking this combo, you need to watch for any symptoms of toxicity such as excess sleepiness, low blood pressure, slowed heart rate, slowed breathing, and excessive nausea or vomiting. I would check with your doctor first before taking this combination and make sure that you have a healthcare professional monitoring your therapy with these two medications. Another side note: make sure you are NOT drinking alcohol while taking these two drugs as it can lead to a lot of nasty side effects (excessive drowsiness, nausea, and vomiting). Best of luck!

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yes it's safe

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